UHRF1 phase separation mediates stable inheritance of DNA methylation and promotes the proliferation of prostate cancer cells

UHRF1 phase separation mediates stable inheritance of DNA methylation and promotes the proliferation of prostate cancer cells

Abstract The primary epigenetic alteration in the development of prostate cancer (PC) is aberrant methylation of the promoter region of tumor suppressor genes. Maintaining DNA methylation activity requires ubiquitin-like PHD and RING finger domain-containing protein 1 (UHRF1). Through its SET and RI...

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Bibliographic Details
Main Authors: Zhean Li, Yihan Wang, Ziqi Yu, Yujia Luo, Yixiang Zhao, Erfei Xue, Junfeng Zhan, Huimin Lu, Fei Sun
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
Subjects:
Prostate cancer
Epigenetic modification
DNA methylation
UHRF1
Phase separation
Online Access:https://doi.org/10.1186/s12964-025-02309-6
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https://doi.org/10.1186/s12964-025-02309-6

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