Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

Abstract Deposition of amyloid‐β (Aβ) as senile plaques is one of the pathological hallmarks in the brains of Alzheimer's disease (AD) patients. In addition, glial activation has been found in AD brains, although the precise pathological role of astrocytes remains unclear. Here, we identified k...

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Main Authors: Kiwami Kidana, Takuya Tatebe, Kaori Ito, Norikazu Hara, Akiyoshi Kakita, Takashi Saito, Sho Takatori, Yasuyoshi Ouchi, Takeshi Ikeuchi, Mitsuhiro Makino, Takaomi C Saido, Masahiro Akishita, Takeshi Iwatsubo, Yukiko Hori, Taisuke Tomita
Format: Article
Language:English
Published: Springer Nature 2018-01-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
amyloid‐β
astrocyte
kallikrein‐related peptidase 7
protease
Online Access:https://doi.org/10.15252/emmm.201708184
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https://doi.org/10.15252/emmm.201708184

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