RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation

RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation

Abstract Targeting metabolic reprogramming is crucial for cancer treatment. Recent advances highlight RNA’s ability to directly regulate enzyme activity through riboregulation. In this study, we used an RNA-based approach to inhibit the mitochondrial enzyme Serine hydroxymethyltransferase 2 (SHMT2),...

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Main Authors: Francesca Romana Liberati, Sharon Spizzichino, Sara Di Russo, Giulia Elizabeth Borsatti, Agnese Riva, Maria Chiara Magnifico, Amani Bouzidi, Giorgio Giardina, Marzia Arese, Chiara Scribani Rossi, Dalila Boi, Giovanna Boumis, Federica Di Fonzo, Giulia Guarguaglini, Roberto Contestabile, Angela Tramonti, Alberto Macone, Alessandro Paiardini, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02646-y
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https://doi.org/10.1038/s41420-025-02646-y

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