Survival and Axonal Regeneration of Retinal Ganglion Cells in a Mouse Optic Nerve Crush Model After a Cell-Based Intravitreal Co-Administration of Ciliary Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor at Different Post-Lesion Time Points

Survival and Axonal Regeneration of Retinal Ganglion Cells in a Mouse Optic Nerve Crush Model After a Cell-Based Intravitreal Co-Administration of Ciliary Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor at Different Post-Lesion Time Points

We recently showed, in a mouse optic nerve crush model, that a sustained cell-based intravitreal administration of ciliary neurotrophic factor (CNTF) and glial cell line-derived neurotrophic factor (GDNF) synergistically slowed the lesion-induced degeneration of retinal ganglion cells (RGCs), result...

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Bibliographic Details
Main Authors: Yue Hu, Lynn Michelle Grodzki, Udo Bartsch
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
ciliary neurotrophic factor
glial cell line-derived neurotrophic factor
neuroprotection
neurotrophic factor
optic neuropathy
regeneration
Online Access:https://www.mdpi.com/2073-4409/14/9/643
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