Restored Collagen VI Microfilaments Network in the Extracellular Matrix of CRISPR-Edited Ullrich Congenital Muscular Dystrophy Fibroblasts

Restored Collagen VI Microfilaments Network in the Extracellular Matrix of CRISPR-Edited Ullrich Congenital Muscular Dystrophy Fibroblasts

Collagen VI is an essential component of the extracellular matrix (ECM) composed by α1, α2 and α3 chains and encoded by <i>COL6A1</i>, <i>COL6A2</i> and <i>COL6A3</i> genes. Dominant negative pathogenic variants in <i>COL6A</i> genes result in defects...

Full description

Saved in:
Bibliographic Details
Main Authors: Daniela Benati, Eleonora Cattin, Federico Corradi, Tommaso Ferrari, Eleonora Pedrazzoli, Clarissa Patrizi, Matteo Marchionni, Roberto Bertorelli, Veronica De Sanctis, Luciano Merlini, Alessandra Ferlini, Patrizia Sabatelli, Francesca Gualandi, Alessandra Recchia
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
CRISPR/Cas9
allele-specific gene editing
collagen VI
collagen VI-related disorders
patient-derived fibroblasts
Online Access:https://www.mdpi.com/2218-273X/14/11/1412
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2218-273X/14/11/1412

Similar Items