Genomic characterization of the HER2-enriched intrinsic molecular subtype in primary ER-positive HER2-negative breast cancer

Genomic characterization of the HER2-enriched intrinsic molecular subtype in primary ER-positive HER2-negative breast cancer

Abstract ER-positive/HER2-negative (ERpHER2n) breast cancer classified as PAM50 HER2-enriched (ERpHER2n-HER2E) represents a small high-risk patient subgroup. In this study, we investigate genomic, transcriptomic, and clinical features of ERpHER2n-HER2E breast tumors using two primary ERpHER2n cohort...

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Main Authors: Lennart Hohmann, Kristin Sigurjonsdottir, Ana Bosch Campos, Deborah F. Nacer, Srinivas Veerla, Frida Rosengren, Poojaswini Thimmaraya Reddy, Jari Häkkinen, Nicklas Nordborg, Johan Vallon-Christersson, Yasin Memari, Daniella Black, Ramsay Bowden, Helen R. Davies, Åke Borg, Serena Nik-Zainal, Johan Staaf
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57419-z
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https://doi.org/10.1038/s41467-025-57419-z

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