Tanshinone IIA alleviates liver fibrosis by suppressing hepatic stellate cell proliferation via ERK/cyclin D1/p-Smad3L signaling axis

Tanshinone IIA alleviates liver fibrosis by suppressing hepatic stellate cell proliferation via ERK/cyclin D1/p-Smad3L signaling axis

Objective(s): Liver fibrosis (LF) is a critical stage in chronic liver disease progression, and effective therapeutic drugs are currently lacking. Tanshinone IIA (Tan IIA), a monomer extracted from Salvia miltiorrhiza, shows potential in treating LF. This research aims to discuss the antifibrotic ef...

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Bibliographic Details
Main Authors: Wenjing Liao, Fang Wu, Zhiyuan Hao, Jinglei Wu, Chenfei Liu, Min Wu, Xiaoman Zhou, Mingze Sun, Yuwei Liu, Meng Fang
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2025-05-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
erk/cyclin d1/p-smad3l - signaling
hepatic stellate cells
liver fibrosis
tanshinone iia
tgf-β1
Online Access:https://ijbms.mums.ac.ir/article_25515_f24b593e5d6bc4d307cc8a896416fc64.pdf
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https://ijbms.mums.ac.ir/article_25515_f24b593e5d6bc4d307cc8a896416fc64.pdf

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