Living Therapeutics for Synergistic Hydrogen‐Photothermal Cancer Treatment by Photosynthetic Bacteria
Abstract Hydrogen gas (H2) therapy, recognized for its inherent biosafety, holds significant promise as an anti‐cancer strategy. However, the efficacy of H2 treatment modalities is compromised by their reliance on systemic gas administration or chemical reactions generation, which suffers from low e...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202408807 |
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| author | Yingyi Zhang Xiaolian Deng Lili Xia Jianghui Liang Meng Chen Xiaoling Xu Wei Chen Jianwei Ding Chengjie Yu Limei Liu Yang Xiang Yiliang Lin Fangfang Duan Wei Feng Yu Chen Xiang Gao |
| author_facet | Yingyi Zhang Xiaolian Deng Lili Xia Jianghui Liang Meng Chen Xiaoling Xu Wei Chen Jianwei Ding Chengjie Yu Limei Liu Yang Xiang Yiliang Lin Fangfang Duan Wei Feng Yu Chen Xiang Gao |
| author_sort | Yingyi Zhang |
| collection | DOAJ |
| description | Abstract Hydrogen gas (H2) therapy, recognized for its inherent biosafety, holds significant promise as an anti‐cancer strategy. However, the efficacy of H2 treatment modalities is compromised by their reliance on systemic gas administration or chemical reactions generation, which suffers from low efficiency, poor targeting, and suboptimal utilization. In this study, living therapeutics are employed using photosynthetic bacteria Rhodobacter sphaeroides for in situ H2 production combined with near‐infrared (NIR) mediated photothermal therapy. Living R. sphaeroides exhibits strong absorption in the NIR spectrum, effectively converting light energy into thermal energy while concurrently generating H2. This dual functionality facilitates the targeted induction of tumor cell death and substantially reduces collateral damage to adjacent normal tissues. The findings reveal that integrating hydrogen therapy with photothermal effects, mediated through photosynthetic bacteria, provides a robust, dual‐modality approach that enhances the overall efficacy of tumor treatments. This living therapeutic strategy not only leverages the therapeutic potential of both hydrogen and photothermal therapeutic modalities but also protects healthy tissues, marking a significant advancement in cancer therapy techniques. |
| format | Article |
| id | doaj-art-c14e94b524f34cac9426200cce01af5f |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-c14e94b524f34cac9426200cce01af5f2025-01-09T11:44:45ZengWileyAdvanced Science2198-38442025-01-01121n/an/a10.1002/advs.202408807Living Therapeutics for Synergistic Hydrogen‐Photothermal Cancer Treatment by Photosynthetic BacteriaYingyi Zhang0Xiaolian Deng1Lili Xia2Jianghui Liang3Meng Chen4Xiaoling Xu5Wei Chen6Jianwei Ding7Chengjie Yu8Limei Liu9Yang Xiang10Yiliang Lin11Fangfang Duan12Wei Feng13Yu Chen14Xiang Gao15Department of Pharmacology School of Medicine Shenzhen Campus of Sun Yat‐Sen University Shenzhen 518107 P. R. ChinaDepartment of Pharmacology School of Medicine Shenzhen Campus of Sun Yat‐Sen University Shenzhen 518107 P. R. ChinaMaterdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. ChinaDepartment of Pharmacology School of Medicine Shenzhen Campus of Sun Yat‐Sen University Shenzhen 518107 P. R. ChinaKey Laboratory of Quantitative Synthetic Biology Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology Chinese Academic of Science Shenzhen 518000 P. R. ChinaDepartment of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Zhejiang 310016 P. R. ChinaDepartment of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Zhejiang 310016 P. R. ChinaDepartment of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 SingaporeDepartment of Pharmacology School of Medicine Shenzhen Campus of Sun Yat‐Sen University Shenzhen 518107 P. R. ChinaDepartment of Pharmacology School of Medicine Shenzhen Campus of Sun Yat‐Sen University Shenzhen 518107 P. R. ChinaDepartment of Pharmacology School of Medicine Shenzhen Campus of Sun Yat‐Sen University Shenzhen 518107 P. R. ChinaDepartment of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 SingaporeDepartment of Pharmacology School of Medicine Shenzhen Campus of Sun Yat‐Sen University Shenzhen 518107 P. R. ChinaMaterdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. ChinaMaterdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. ChinaKey Laboratory of Quantitative Synthetic Biology Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology Chinese Academic of Science Shenzhen 518000 P. R. ChinaAbstract Hydrogen gas (H2) therapy, recognized for its inherent biosafety, holds significant promise as an anti‐cancer strategy. However, the efficacy of H2 treatment modalities is compromised by their reliance on systemic gas administration or chemical reactions generation, which suffers from low efficiency, poor targeting, and suboptimal utilization. In this study, living therapeutics are employed using photosynthetic bacteria Rhodobacter sphaeroides for in situ H2 production combined with near‐infrared (NIR) mediated photothermal therapy. Living R. sphaeroides exhibits strong absorption in the NIR spectrum, effectively converting light energy into thermal energy while concurrently generating H2. This dual functionality facilitates the targeted induction of tumor cell death and substantially reduces collateral damage to adjacent normal tissues. The findings reveal that integrating hydrogen therapy with photothermal effects, mediated through photosynthetic bacteria, provides a robust, dual‐modality approach that enhances the overall efficacy of tumor treatments. This living therapeutic strategy not only leverages the therapeutic potential of both hydrogen and photothermal therapeutic modalities but also protects healthy tissues, marking a significant advancement in cancer therapy techniques.https://doi.org/10.1002/advs.202408807hydrogen therapyhydrogen‐photothermal therapyliving bacterial therapiesphotosynthetic bacteria |
| spellingShingle | Yingyi Zhang Xiaolian Deng Lili Xia Jianghui Liang Meng Chen Xiaoling Xu Wei Chen Jianwei Ding Chengjie Yu Limei Liu Yang Xiang Yiliang Lin Fangfang Duan Wei Feng Yu Chen Xiang Gao Living Therapeutics for Synergistic Hydrogen‐Photothermal Cancer Treatment by Photosynthetic Bacteria Advanced Science hydrogen therapy hydrogen‐photothermal therapy living bacterial therapies photosynthetic bacteria |
| title | Living Therapeutics for Synergistic Hydrogen‐Photothermal Cancer Treatment by Photosynthetic Bacteria |
| title_full | Living Therapeutics for Synergistic Hydrogen‐Photothermal Cancer Treatment by Photosynthetic Bacteria |
| title_fullStr | Living Therapeutics for Synergistic Hydrogen‐Photothermal Cancer Treatment by Photosynthetic Bacteria |
| title_full_unstemmed | Living Therapeutics for Synergistic Hydrogen‐Photothermal Cancer Treatment by Photosynthetic Bacteria |
| title_short | Living Therapeutics for Synergistic Hydrogen‐Photothermal Cancer Treatment by Photosynthetic Bacteria |
| title_sort | living therapeutics for synergistic hydrogen photothermal cancer treatment by photosynthetic bacteria |
| topic | hydrogen therapy hydrogen‐photothermal therapy living bacterial therapies photosynthetic bacteria |
| url | https://doi.org/10.1002/advs.202408807 |
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