Paxilline derived from an endophytic fungus of Baphicacanthus cusia alleviates hepatocellular carcinoma through autophagy-mediated apoptosis

Paxilline derived from an endophytic fungus of Baphicacanthus cusia alleviates hepatocellular carcinoma through autophagy-mediated apoptosis

Abstract Hepatocellular carcinoma (HCC) is a malignancy for which no effective drugs are available. Paxilline is derived from an endophytic fungus of the leaves of Baphicacanthus cusia (Nees) Bremek. In a previous study, we found that paxilline inhibited the proliferation of HepG2 cells; however, it...

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Bibliographic Details
Main Authors: Yin Yuan, Jing Yu, Meng Li, Tian Zhou, Zhaoyou Deng, Cuiyun Yin, Xuanchao Shi, Deying Tang, Yiran Liu, Yihang Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Paxilline
Hepatocellular carcinoma
Network pharmacology
Apoptosis
Autophagy
Online Access:https://doi.org/10.1038/s41598-025-03044-1
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https://doi.org/10.1038/s41598-025-03044-1

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