Inhibiting parasite proliferation using a rationally designed anti‐tubulin agent

Inhibiting parasite proliferation using a rationally designed anti‐tubulin agent

Abstract Infectious diseases caused by apicomplexan parasites remain a global public health threat. The presence of multiple ligand‐binding sites in tubulin makes this protein an attractive target for anti‐parasite drug discovery. However, despite remarkable successes as anti‐cancer agents, the rati...

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Bibliographic Details
Main Authors: Natacha Gaillard, Ashwani Sharma, Izra Abbaali, Tianyang Liu, Fiona Shilliday, Alexander D Cook, Valentin Ehrhard, Mamata Bangera, Anthony J Roberts, Carolyn A Moores, Naomi Morrissette, Michel O Steinmetz
Format: Article
Language:English
Published: Springer Nature 2021-10-01
Series:EMBO Molecular Medicine
Subjects:
anti‐parasite
microtubules
rational structure‐based drug design
species‐specific tubulin inhibitor
Online Access:https://doi.org/10.15252/emmm.202013818
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https://doi.org/10.15252/emmm.202013818

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