A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration
Abstract The clinical course and treatment of neurodegenerative disease are complicated by immune-system interference and chronic inflammatory processes, which remain incompletely understood. Mapping immune signatures in larger human cohorts through single-cell gene expression profiling supports our...
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56833-7 |
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| author | Friederike Grandke Tobias Fehlmann Fabian Kern David M. Gate Tobias William Wolff Olivia Leventhal Divya Channappa Pascal Hirsch Edward N. Wilson Eckart Meese Chuanyu Liu Quan Shi Matthias Flotho Yongping Li Cynthia Chen Yeya Yu Jiangshan Xu Michael Junkin Zhifeng Wang Tao Wu Longqi Liu Yong Hou Katrin I. Andreasson Jenny S. Gansen Elvira Mass Kathleen Poston Tony Wyss-Coray Andreas Keller |
| author_facet | Friederike Grandke Tobias Fehlmann Fabian Kern David M. Gate Tobias William Wolff Olivia Leventhal Divya Channappa Pascal Hirsch Edward N. Wilson Eckart Meese Chuanyu Liu Quan Shi Matthias Flotho Yongping Li Cynthia Chen Yeya Yu Jiangshan Xu Michael Junkin Zhifeng Wang Tao Wu Longqi Liu Yong Hou Katrin I. Andreasson Jenny S. Gansen Elvira Mass Kathleen Poston Tony Wyss-Coray Andreas Keller |
| author_sort | Friederike Grandke |
| collection | DOAJ |
| description | Abstract The clinical course and treatment of neurodegenerative disease are complicated by immune-system interference and chronic inflammatory processes, which remain incompletely understood. Mapping immune signatures in larger human cohorts through single-cell gene expression profiling supports our understanding of observed peripheral changes in neurodegeneration. Here, we employ single-cell gene expression profiling of over 909k peripheral blood mononuclear cells (PBMCs) from 121 healthy individuals, 48 patients with mild cognitive impairment (MCI), 46 with Parkinson’s disease (PD), 27 with Alzheimer’s disease (AD), and 15 with both PD and MCI. The dataset is interactively accessible through a freely available website ( https://www.ccb.uni-saarland.de/adrcsc ). In this work, we identify disease-associated changes in blood cell type composition and the gene expression in a sex-specific manner, offering insights into peripheral and solid tissue signatures in AD and PD. |
| format | Article |
| id | doaj-art-c0e2f25d396e463a928640b6d1336995 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-c0e2f25d396e463a928640b6d13369952025-08-20T02:01:38ZengNature PortfolioNature Communications2041-17232025-02-0116111310.1038/s41467-025-56833-7A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegenerationFriederike Grandke0Tobias Fehlmann1Fabian Kern2David M. Gate3Tobias William Wolff4Olivia Leventhal5Divya Channappa6Pascal Hirsch7Edward N. Wilson8Eckart Meese9Chuanyu Liu10Quan Shi11Matthias Flotho12Yongping Li13Cynthia Chen14Yeya Yu15Jiangshan Xu16Michael Junkin17Zhifeng Wang18Tao Wu19Longqi Liu20Yong Hou21Katrin I. Andreasson22Jenny S. Gansen23Elvira Mass24Kathleen Poston25Tony Wyss-Coray26Andreas Keller27Clinical Bioinformatics, Saarland UniversityClinical Bioinformatics, Saarland UniversityClinical Bioinformatics, Saarland UniversityDepartment of Neurology and Neurological Sciences, Stanford UniversityClinical Bioinformatics, Saarland UniversityDepartment of Neurology and Neurological Sciences, Stanford UniversityDepartment of Neurology and Neurological Sciences, Stanford UniversityClinical Bioinformatics, Saarland UniversityDepartment of Neurology and Neurological Sciences, Stanford UniversityDepartment of Human Genetics, Saarland UniversityMGI GroupMGI GroupClinical Bioinformatics, Saarland UniversityClinical Bioinformatics, Saarland UniversityMGI GroupMGI GroupMGI GroupMGI GroupMGI GroupMGI GroupMGI GroupMGI GroupDepartment of Neurology and Neurological Sciences, Stanford UniversityClinical Bioinformatics, Saarland UniversityLife and Medical Sciences Institute, Developmental Biology of the Immune System, University of BonnDepartment of Neurology and Neurological Sciences, Stanford UniversityDepartment of Neurology and Neurological Sciences, Stanford UniversityClinical Bioinformatics, Saarland UniversityAbstract The clinical course and treatment of neurodegenerative disease are complicated by immune-system interference and chronic inflammatory processes, which remain incompletely understood. Mapping immune signatures in larger human cohorts through single-cell gene expression profiling supports our understanding of observed peripheral changes in neurodegeneration. Here, we employ single-cell gene expression profiling of over 909k peripheral blood mononuclear cells (PBMCs) from 121 healthy individuals, 48 patients with mild cognitive impairment (MCI), 46 with Parkinson’s disease (PD), 27 with Alzheimer’s disease (AD), and 15 with both PD and MCI. The dataset is interactively accessible through a freely available website ( https://www.ccb.uni-saarland.de/adrcsc ). In this work, we identify disease-associated changes in blood cell type composition and the gene expression in a sex-specific manner, offering insights into peripheral and solid tissue signatures in AD and PD.https://doi.org/10.1038/s41467-025-56833-7 |
| spellingShingle | Friederike Grandke Tobias Fehlmann Fabian Kern David M. Gate Tobias William Wolff Olivia Leventhal Divya Channappa Pascal Hirsch Edward N. Wilson Eckart Meese Chuanyu Liu Quan Shi Matthias Flotho Yongping Li Cynthia Chen Yeya Yu Jiangshan Xu Michael Junkin Zhifeng Wang Tao Wu Longqi Liu Yong Hou Katrin I. Andreasson Jenny S. Gansen Elvira Mass Kathleen Poston Tony Wyss-Coray Andreas Keller A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration Nature Communications |
| title | A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration |
| title_full | A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration |
| title_fullStr | A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration |
| title_full_unstemmed | A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration |
| title_short | A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration |
| title_sort | single cell atlas to map sex specific gene expression changes in blood upon neurodegeneration |
| url | https://doi.org/10.1038/s41467-025-56833-7 |
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