A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

Abstract The clinical course and treatment of neurodegenerative disease are complicated by immune-system interference and chronic inflammatory processes, which remain incompletely understood. Mapping immune signatures in larger human cohorts through single-cell gene expression profiling supports our...

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Main Authors: Friederike Grandke, Tobias Fehlmann, Fabian Kern, David M. Gate, Tobias William Wolff, Olivia Leventhal, Divya Channappa, Pascal Hirsch, Edward N. Wilson, Eckart Meese, Chuanyu Liu, Quan Shi, Matthias Flotho, Yongping Li, Cynthia Chen, Yeya Yu, Jiangshan Xu, Michael Junkin, Zhifeng Wang, Tao Wu, Longqi Liu, Yong Hou, Katrin I. Andreasson, Jenny S. Gansen, Elvira Mass, Kathleen Poston, Tony Wyss-Coray, Andreas Keller
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56833-7
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https://doi.org/10.1038/s41467-025-56833-7

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