Oligodendrocyte-specific overexpression of human alpha-synuclein results in elevated MBP levels and inflammatory responses in TgM83 mice, mimicking the pathological features of multiple system atrophy

Oligodendrocyte-specific overexpression of human alpha-synuclein results in elevated MBP levels and inflammatory responses in TgM83 mice, mimicking the pathological features of multiple system atrophy

Abstract Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by parkinsonism, cerebellar dysfunction, and autonomic failure. Key pathological features of MSA include the formation of glial cytoplasmic inclusions (GCIs) in oligodendrocytes (OLs), myelin loss, and neuroinflamma...

Full description

Saved in:
Bibliographic Details
Main Authors: Sam Chi-Hao Liu, Koping Chang, Meng-Ling Chen, Ming-Che Kuo, Teh-Cheng Wang, Ruey-Meei Wu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
MBP
AAVOlig001
TgM83 mice
Alpha-synucleinopathy
Inflammation responses
MSA
Online Access:https://doi.org/10.1186/s40478-025-02014-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s40478-025-02014-y

Similar Items