Impact of standardized immunophenotyping and MRD monitoring on early mortality reduction in childhood leukemia: a step towards addressing healthcare disparities in vulnerable populations from Southern Mexico

Impact of standardized immunophenotyping and MRD monitoring on early mortality reduction in childhood leukemia: a step towards addressing healthcare disparities in vulnerable populations from Southern Mexico

BackgroundDespite high cure rates for pediatric B-cell acute lymphoblastic leukemia (B-ALL) in high-income countries, early mortality remains unacceptably high in low- and middle-income countries (LMICs), largely due to limited access to risk-adapted therapy and response monitoring. Southern Mexico,...

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Main Authors: Laura Alfaro-Hernández, Dalia Ramírez-Ramírez, Rubí Romo-Rodríguez, Karen Ayala-Contreras, Ángeles del Campo-Martínez, Enrique López-Aguilar, Janet Flores Lujano, Aldo Allende-López, Erika Alarcón-Ruiz, Ma Del Rocio Banos-Lara, Diana Casique-Aguirre, Jesús Elizarrarás-Rivas, Javier Antonio López-Aquino, Miguel Ángel Garrido-Hernández, Daniela Olvera-Caraza, Vanessa Terán-Cerqueda, Juan Carlos Solís-Poblano, Pierre Mitchel Aristil-Chery, Enoch Alvarez-Rodríguez, Wilfrido Herrera-Olivares, Lénica Anahí Chavez-Aguilar, Aquilino Márquez-Toledo, Lena Sarahi Cano-Cuapio, Nuria Citlalli Luna-Silva, Maria Angélica Martínez-Martell, Anabel Beatriz Ramirez-Ramirez, Juan Carlos Rodríguez-Espinosa, Daniela Medina-León, Roberto Rodríguez-Díaz, Minerva Mata-Rocha, Amanda Idaric Olivares-Sosa, Haydeé Rosas-Vargas, Juan Manuel Mejia-Arangure, Lourdes Millán-Pérez-Peña, Rosana Pelayo, Juan Carlos Núñez-Enríquez
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
pediatric B-cell acute lymphoblastic leukemia
immunophenotyping
measurable residual disease (MRD)
early-mortality
low-and middle -income countries
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1614445/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1614445/full

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