Deciphering tryptophan metabolism in colorectal cancer through multi-omics analysis

Deciphering tryptophan metabolism in colorectal cancer through multi-omics analysis

Metabolic reprogramming is essential for colorectal cancer (CRC) progression, and recent studies have pointed to tryptophan metabolism as a crucial modulator of the tumor immune microenvironment. In this study, we performed untargeted metabolomics analyses and identified significant differences betw...

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Main Authors: Chengcheng Zhang, Zhijing Rao, Xiangyang Zhan, Jingru Qin, Lu Yang, Qianqian Yin, Junqing Ji, Xiaoxue Zhao, Yiyi Liu, Zhanhui Lu, Guoying Wang, Xingshuai Huang, Wenbo Shi, Wan Su, Zhongqi Wang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Colorectal cancer
Tryptophan metabolism
Metabolomics
Tumor microenvironment
Macrophage polarization
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825002444
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