Characterization of recombinant human lysosomal beta-hexosaminidases produced in the methylotrophic yeast Pichia pastoris

Characterization of recombinant human lysosomal beta-hexosaminidases produced in the methylotrophic yeast Pichia pastoris

β-hexosaminidases (Hex) are dimeric enzymes involved in the lysosomal degradation of glycolipids and glycans. They are formed by α- and/or β-subunits encoded byHEXA and HEXB genes, respectively. Mutations in these genes lead to Tay Sachs or Sandhoff diseases, which are neurodegenerative disorders ca...

Full description

Saved in:
Bibliographic Details
Main Authors: Angela Johana Espejo Mojica, Angela Rocío Mosquera, Edwin Alexander Rodríguez-López, Dennis Johana Díaz, Laura Milena Betrán, Francy Liliana Hernández, Carlos Javier Alméciga Díaz, Luis Alejandro Barrera
Format: Article
Language:English
Published: Pontificia Universidad Javeriana 2016-08-01
Series:Universitas Scientiarum
Subjects:
β-N-acetylhexosaminidases; characterization; Pichia pastoris; recombinant hexosaminidases; Sandhoff disease
β-N-acetylhexosaminidases
characterization
Pichia pastoris
recombinant hexosaminidases
Sandhoff disease
Tay Sachs disease.
Online Access:http://revistas.javeriana.edu.co/index.php/scientarium/article/view/15736
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://revistas.javeriana.edu.co/index.php/scientarium/article/view/15736

Similar Items