Sodium butyrate and sodium propionate inhibit breast cancer cell migration and invasion through regulation of epithelial-to-mesenchymal transition and suppression of MEK/ERK signaling pathway

Sodium butyrate and sodium propionate inhibit breast cancer cell migration and invasion through regulation of epithelial-to-mesenchymal transition and suppression of MEK/ERK signaling pathway

ObjectiveThis study aims to investigate the roles played by NaB and NaP in breast carcinogenesis by elucidating their potential anti-metastatic effects in the context of tumor migration, invasion, and EMT regulation in two distinct breast cancer cell lines, MCF-7 and MDA-MB-231.MethodsThe cytotoxic...

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Bibliographic Details
Main Authors: Dania Mahmoud Kharazi, Louna Karam, Charbel El Boustany, José-Noel Ibrahim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
breast cancer
short chain fatty acids (SCFAs)
migration
invasion
epithelial-to-mesenchymal transition (EMT)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1535563/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1535563/full

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