Impact of Tat Genetic Variation on HIV-1 Disease
The human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in transcriptional activation of HIV-1 gene expression. Functional...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2012/123605 |
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| _version_ | 1832554113353646080 |
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| author | Luna Li Satinder Dahiya Sandhya Kortagere Benjamas Aiamkitsumrit David Cunningham Vanessa Pirrone Michael R. Nonnemacher Brian Wigdahl |
| author_facet | Luna Li Satinder Dahiya Sandhya Kortagere Benjamas Aiamkitsumrit David Cunningham Vanessa Pirrone Michael R. Nonnemacher Brian Wigdahl |
| author_sort | Luna Li |
| collection | DOAJ |
| description | The human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in transcriptional activation of HIV-1 gene expression. Functional domains of Tat and its interaction with transactivation response element RNA and cellular transcription factors have been examined. Genetic variation within tat of different HIV-1 subtypes has been shown to affect the interaction of the viral transactivator with cellular and/or viral proteins, influencing the overall level of transcriptional activation as well as its action as a neurotoxic protein. Consequently, the genetic variability within tat may impact the molecular architecture of functional domains of the Tat protein that may impact HIV pathogenesis and disease. Tat as a therapeutic target for anti-HIV drugs has also been discussed. |
| format | Article |
| id | doaj-art-c08105853f2041b6916e60d93e9af414 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-c08105853f2041b6916e60d93e9af4142025-02-03T05:52:22ZengWileyAdvances in Virology1687-86391687-86472012-01-01201210.1155/2012/123605123605Impact of Tat Genetic Variation on HIV-1 DiseaseLuna Li0Satinder Dahiya1Sandhya Kortagere2Benjamas Aiamkitsumrit3David Cunningham4Vanessa Pirrone5Michael R. Nonnemacher6Brian Wigdahl7Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USADepartment of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USADepartment of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USADepartment of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USADepartment of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USADepartment of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USADepartment of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USADepartment of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USAThe human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in transcriptional activation of HIV-1 gene expression. Functional domains of Tat and its interaction with transactivation response element RNA and cellular transcription factors have been examined. Genetic variation within tat of different HIV-1 subtypes has been shown to affect the interaction of the viral transactivator with cellular and/or viral proteins, influencing the overall level of transcriptional activation as well as its action as a neurotoxic protein. Consequently, the genetic variability within tat may impact the molecular architecture of functional domains of the Tat protein that may impact HIV pathogenesis and disease. Tat as a therapeutic target for anti-HIV drugs has also been discussed.http://dx.doi.org/10.1155/2012/123605 |
| spellingShingle | Luna Li Satinder Dahiya Sandhya Kortagere Benjamas Aiamkitsumrit David Cunningham Vanessa Pirrone Michael R. Nonnemacher Brian Wigdahl Impact of Tat Genetic Variation on HIV-1 Disease Advances in Virology |
| title | Impact of Tat Genetic Variation on HIV-1 Disease |
| title_full | Impact of Tat Genetic Variation on HIV-1 Disease |
| title_fullStr | Impact of Tat Genetic Variation on HIV-1 Disease |
| title_full_unstemmed | Impact of Tat Genetic Variation on HIV-1 Disease |
| title_short | Impact of Tat Genetic Variation on HIV-1 Disease |
| title_sort | impact of tat genetic variation on hiv 1 disease |
| url | http://dx.doi.org/10.1155/2012/123605 |
| work_keys_str_mv | AT lunali impactoftatgeneticvariationonhiv1disease AT satinderdahiya impactoftatgeneticvariationonhiv1disease AT sandhyakortagere impactoftatgeneticvariationonhiv1disease AT benjamasaiamkitsumrit impactoftatgeneticvariationonhiv1disease AT davidcunningham impactoftatgeneticvariationonhiv1disease AT vanessapirrone impactoftatgeneticvariationonhiv1disease AT michaelrnonnemacher impactoftatgeneticvariationonhiv1disease AT brianwigdahl impactoftatgeneticvariationonhiv1disease |