Classifications of triple-negative breast cancer: insights and current therapeutic approaches
Abstract Triple-negative breast cancer (TNBC) is an aggressive and challenging type of cancer, characterized by the absence of specific receptors targeted by current therapies, which limits effective targeted treatment options. TNBC has a high risk of recurrence and distant metastasis, resulting in...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-025-01359-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571264350289920 |
|---|---|
| author | Ziqi Chen Yumeng Liu Minchuan Lyu Chi Ho Chan Meiheng Sun Xin Yang Shuangying Qiao Zheng Chen Sifan Yu Meishen Ren Aiping Lu Ge Zhang Fangfei Li Yuanyuan Yu |
| author_facet | Ziqi Chen Yumeng Liu Minchuan Lyu Chi Ho Chan Meiheng Sun Xin Yang Shuangying Qiao Zheng Chen Sifan Yu Meishen Ren Aiping Lu Ge Zhang Fangfei Li Yuanyuan Yu |
| author_sort | Ziqi Chen |
| collection | DOAJ |
| description | Abstract Triple-negative breast cancer (TNBC) is an aggressive and challenging type of cancer, characterized by the absence of specific receptors targeted by current therapies, which limits effective targeted treatment options. TNBC has a high risk of recurrence and distant metastasis, resulting in lower survival rates. Additionally, TNBC exhibits significant heterogeneity at histopathological, proteomic, transcriptomic, and genomic levels, further complicating the development of effective treatments. While some TNBC subtypes may initially respond to chemotherapy, resistance frequently develops, increasing the risk of aggressive recurrence. Therefore, precisely classifying and characterizing the distinct features of TNBC subtypes is crucial for identifying the most suitable molecular-based therapies for individual patients. In this review, we provide a comprehensive overview of these subtypes, highlighting their unique profiles as defined by various classification systems. We also address the limitations of conventional therapeutic approaches and explore innovative biological strategies, all aimed at advancing the development of targeted and effective therapeutic strategies for TNBC. |
| format | Article |
| id | doaj-art-c0637400b1f74a82b68a8a44f05b9cac |
| institution | Kabale University |
| issn | 2045-3701 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj-art-c0637400b1f74a82b68a8a44f05b9cac2025-02-02T12:44:25ZengBMCCell & Bioscience2045-37012025-02-0115111610.1186/s13578-025-01359-0Classifications of triple-negative breast cancer: insights and current therapeutic approachesZiqi Chen0Yumeng Liu1Minchuan Lyu2Chi Ho Chan3Meiheng Sun4Xin Yang5Shuangying Qiao6Zheng Chen7Sifan Yu8Meishen Ren9Aiping Lu10Ge Zhang11Fangfei Li12Yuanyuan Yu13Institute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityGuangdong-Hong Kong-Macao Greater Bay Area International Research Platform for Aptamer-Based Translational Medicine and Drug DiscoveryInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist UniversityAbstract Triple-negative breast cancer (TNBC) is an aggressive and challenging type of cancer, characterized by the absence of specific receptors targeted by current therapies, which limits effective targeted treatment options. TNBC has a high risk of recurrence and distant metastasis, resulting in lower survival rates. Additionally, TNBC exhibits significant heterogeneity at histopathological, proteomic, transcriptomic, and genomic levels, further complicating the development of effective treatments. While some TNBC subtypes may initially respond to chemotherapy, resistance frequently develops, increasing the risk of aggressive recurrence. Therefore, precisely classifying and characterizing the distinct features of TNBC subtypes is crucial for identifying the most suitable molecular-based therapies for individual patients. In this review, we provide a comprehensive overview of these subtypes, highlighting their unique profiles as defined by various classification systems. We also address the limitations of conventional therapeutic approaches and explore innovative biological strategies, all aimed at advancing the development of targeted and effective therapeutic strategies for TNBC.https://doi.org/10.1186/s13578-025-01359-0Triple-negative breast cancerClassificationSubtypeTumor heterogeneityNeoadjuvant therapy |
| spellingShingle | Ziqi Chen Yumeng Liu Minchuan Lyu Chi Ho Chan Meiheng Sun Xin Yang Shuangying Qiao Zheng Chen Sifan Yu Meishen Ren Aiping Lu Ge Zhang Fangfei Li Yuanyuan Yu Classifications of triple-negative breast cancer: insights and current therapeutic approaches Cell & Bioscience Triple-negative breast cancer Classification Subtype Tumor heterogeneity Neoadjuvant therapy |
| title | Classifications of triple-negative breast cancer: insights and current therapeutic approaches |
| title_full | Classifications of triple-negative breast cancer: insights and current therapeutic approaches |
| title_fullStr | Classifications of triple-negative breast cancer: insights and current therapeutic approaches |
| title_full_unstemmed | Classifications of triple-negative breast cancer: insights and current therapeutic approaches |
| title_short | Classifications of triple-negative breast cancer: insights and current therapeutic approaches |
| title_sort | classifications of triple negative breast cancer insights and current therapeutic approaches |
| topic | Triple-negative breast cancer Classification Subtype Tumor heterogeneity Neoadjuvant therapy |
| url | https://doi.org/10.1186/s13578-025-01359-0 |
| work_keys_str_mv | AT ziqichen classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT yumengliu classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT minchuanlyu classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT chihochan classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT meihengsun classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT xinyang classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT shuangyingqiao classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT zhengchen classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT sifanyu classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT meishenren classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT aipinglu classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT gezhang classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT fangfeili classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches AT yuanyuanyu classificationsoftriplenegativebreastcancerinsightsandcurrenttherapeuticapproaches |