UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans

UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans

BackgroundDabigatran etexilate (DABE), a prodrug of dabigatran (DAB), is a direct thrombin inhibitor used to prevent ischemic stroke and thromboembolism during atrial fibrillation. The effect of genetic polymorphisms on its metabolism, particularly UGT2B15, has not been extensively explored in human...

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Bibliographic Details
Main Authors:	Jin-Woo Park, Jong-Min Kim, Young Yoon Bang, Kyoung-Ah Kim, Sungwook Yu, Ji-Young Park
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Pharmacology
Subjects:	dabigatran UGT2B15 genetic polymorphism pharmacokinetics dabigatran acylglucuronide
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1507915/full
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