Gram-positive probiotics improves acetaminophen-induced hepatotoxicity by inhibiting leucine and Hippo-YAP pathway

Gram-positive probiotics improves acetaminophen-induced hepatotoxicity by inhibiting leucine and Hippo-YAP pathway

Abstract Objectives Drug-induced liver injury (DILI) can be improved by modulating gut microbiota. We aimed to investigate a probiotic mixture comprising Bifidobacterium Longum, Streptococcus thermophilus, and Lactobacillus delbrueckii subspecies bulgaricus (BSL) in mitigating acetaminophen induced...

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Main Authors: Wenkang Gao, Gang Wang, Hang Yuan, Yue Chen, Jiake Che, Zilu Cheng, Liuying Chen, Li Zhang, Yuanqing Zhu, Xin Liu, Ao Liu, Quancheng Yang, Peng Cao, Wei Qian, Weiyan Huang, Bernd Schnabl, Ling Yang, Huikuan Chu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell & Bioscience
Subjects:
Acetaminophen
Dysbiosis
Probiotics
Gut-liver axis
Branched-chain amino acids
Gut microbiome
Online Access:https://doi.org/10.1186/s13578-025-01370-5
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https://doi.org/10.1186/s13578-025-01370-5

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