Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis.

Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis.

Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a major global health problem, despite the widespread use of the M. bovis Bacille Calmette-Guerin (BCG) vaccine and the availability of drug therapies. In recent years, the high incidence of coinfection of M. tuberculosis and HIV, as wel...

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Main Authors: Joseph Hinchey, Bo Y Jeon, Holly Alley, Bing Chen, Michael Goldberg, Steven Derrick, Sheldon Morris, William R Jacobs, Steven A Porcelli, Sunhee Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015857&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015857&type=printable

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