A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages

A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages

Abstract Long noncoding RNAs (lncRNA) are crucial yet underexplored regulators of human immunity. Here we develop GRADR, a method integrating gradient profiling with RNA-binding proteome analysis, to map the protein interactomes of all expressed RNAs in a single experiment to study mechanisms of lnc...

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Main Authors: Nils Schmerer, Harshavardhan Janga, Michelle Aillaud, Janina Hoffmann, Marina Aznaourova, Sarah Wende, Henrike Steding, Luke D. Halder, Michael Uhl, Fabian Boldt, Thorsten Stiewe, Andrea Nist, Lukas Jerrentrup, Andreas Kirschbaum, Clemens Ruppert, Oliver Rossbach, Evgenia Ntini, Annalisa Marsico, Chanil Valasarajan, Rolf Backofen, Uwe Linne, Soni S. Pullamsetti, Bernd Schmeck, Leon N. Schulte
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60084-x
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https://doi.org/10.1038/s41467-025-60084-x

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