In silico design of DNA aptamers targeting the GGEEF domain to disrupt biofilm-mediated resistance in Vibrio cholerae: a molecular dynamics study

In silico design of DNA aptamers targeting the GGEEF domain to disrupt biofilm-mediated resistance in Vibrio cholerae: a molecular dynamics study

Abstract The emergence of multidrug-resistant (MDR) Vibrio cholerae is influenced by chromosomal mutations, gene transfer, and biofilm formation, with the GGEEF domain playing a crucial role in regulating biofilm through c-di-GMP signaling. Conventional antimicrobial strategies often struggle to add...

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Bibliographic Details
Main Authors: Lakshana Bakthavachalam, Karthikraja Sakthivel, Sudharsan Muruganantham, Sonalikaa Subramanian, Ram Kothandan
Format: Article
Language:English
Published: Springer Nature 2025-08-01
Series:Discover Molecules
Subjects:
DNA aptamer
Molecular glues
Molecular dynamics
Multidrug resistance
Online Access:https://doi.org/10.1007/s44345-025-00025-9
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https://doi.org/10.1007/s44345-025-00025-9

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