Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma

Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma

Abstract Members from the RAS GTPase superfamily have been closely implicated in the tumorigenesis of various human cancers. Recent sequencing analysis of lung adenocarcinoma has revealed the prevalence of alterations in the RIT1 gene that is a close RAS paralog. However, relative to RAS subfamily m...

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Main Authors: Ruilan Ma, Dian Yang, Peng Wang, Ziyi Zhang, Xuehong Zhang, Jialiang Song, Han Liu, Shuyan Liu, Yingqiu Zhang, Lijuan Zou
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Biology Direct
Subjects:
Lung adenocarcinoma
RAS family
RIT1
GTPase
Ferroptosis
Oncogenic mutation
Online Access:https://doi.org/10.1186/s13062-025-00613-2
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https://doi.org/10.1186/s13062-025-00613-2

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