Discovery of a Novel Dual Targeting Peptide for Human Glioma: From In Silico Simulation to Acting as Targeting Ligand

Discovery of a Novel Dual Targeting Peptide for Human Glioma: From In Silico Simulation to Acting as Targeting Ligand

Purpose: Receptor-mediated transcytosis (RMT) is a more specific, highly efficient, and reliable approach to crossing the blood-brain-barrier (BBB) and releasing the therapeutic cargos into the brain parenchyma. Methods: Here, we introduced and characterized a human/mouse-specific novel leptin-deriv...

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Bibliographic Details
Main Authors: Negar Sedghi Aminabad, Yousef Saeedi, Jamal Adiban, Mahdieh Nemati, Donya Shaterabadi, Farhood Najafi, Reza Rahbarghazi, Mehdi Talebi, Amir Zarebkohan
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2024-07-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
leptin-derived peptide
md simulation
receptor-mediated transcytosis
glioma
brain targeting
pamam dendrimer
in vivo
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-14-453.pdf
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https://apb.tbzmed.ac.ir/PDF/apb-14-453.pdf

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