Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery

Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery

Abstract Lipid droplets (LDs) are crucial for energy homeostasis, but are also involved in a wide spectrum of other cellular processes. Accumulating data identifies LDs as an important player in inflammation. However, the underlying mechanisms and the impact of LDs on neuroinflammation remain unclea...

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Main Authors: Chiara Beretta, Abdulkhalek Dakhel, Khalid Eltom, Fredrik Rosqvist, Simon Uzoni, Tobias Mothes, John S. Fletcher, Ulf Risérus, Dag Sehlin, Jinar Rostami, Wojciech Piotr Michno, Anna Erlandsson
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Neuroinflammation
Subjects:
Astrocytes
Lipid droplets
Antigen presentation
Neuroinflammation
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s12974-025-03452-0
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https://doi.org/10.1186/s12974-025-03452-0

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