Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida

Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida

Abstract Although synthetic biology can produce valuable chemicals in a renewable manner, its progress is still hindered by a lack of predictive capabilities. Media optimization is a critical, and often overlooked, process which is essential to obtain the titers, rates and yields needed for commerci...

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Main Authors: Apostolos Zournas, Matthew R. Incha, Tijana Radivojevic, Vincent Blay, Jose Manuel Martí, Zak Costello, Matthias Schmidt, Tan Chung, Mitchell G. Thompson, Allison Pearson, Patrick C. Kinnunen, Thomas Eng, Christopher E. Lawson, Stephen Tan, Tadeusz Ogorzalek, Nurgul Kaplan, Mark Forrer, Tyler Backman, Aindrila Mukhopadhyay, Nathan J. Hillson, Jay D. Keasling, Hector Garcia Martin
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08039-2
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https://doi.org/10.1038/s42003-025-08039-2

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