Genome‐scale gene/reaction essentiality and synthetic lethality analysis

Abstract Synthetic lethals are to pairs of non‐essential genes whose simultaneous deletion prohibits growth. One can extend the concept of synthetic lethality by considering gene groups of increasing size where only the simultaneous elimination of all genes is lethal, whereas individual gene deletio...

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Bibliographic Details
Main Authors: Patrick F Suthers, Alireza Zomorrodi, Costas D Maranas
Format: Article
Language:English
Published: Springer Nature 2009-08-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.1038/msb.2009.56
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