Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice
Abstract The impact of exosomes derived from patients with High Altitude Cerebral Edema (HACE) on cognitive function in mice was investigated, along with the underlying mechanisms. Exosomes were extracted from HACE patients and injected into the dentate gyrus (DG) of mice. A series of behavioral tes...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-07-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-025-03469-2 |
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| _version_ | 1849332016865083392 |
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| author | Qiang Fu Rui Qiu Quan Tang Xiaodong Li Yaobo Li Yuxiang Qin Qiaosheng Li Jia Yao Zhongyong Jiang Huan Xu Yong Cheng |
| author_facet | Qiang Fu Rui Qiu Quan Tang Xiaodong Li Yaobo Li Yuxiang Qin Qiaosheng Li Jia Yao Zhongyong Jiang Huan Xu Yong Cheng |
| author_sort | Qiang Fu |
| collection | DOAJ |
| description | Abstract The impact of exosomes derived from patients with High Altitude Cerebral Edema (HACE) on cognitive function in mice was investigated, along with the underlying mechanisms. Exosomes were extracted from HACE patients and injected into the dentate gyrus (DG) of mice. A series of behavioral tests assessed cognitive abilities. Results indicated that mice injected with HACE patient exosomes exhibited significant declines in exploratory behavior and object recognition, suggesting notable cognitive impairments. Additionally, these exosomes induced oxidative stress responses and abnormal activation of microglia, closely associated with neuronal death. Proteomic analysis revealed that the differentially expressed protein STAMBP, which is closely linked to neurodevelopment, may play a key role. In conclusion, our findings highlight the potential impact of exosomes from HACE patients on cognitive dysfunction in mice, providing new insights into the pathophysiological mechanisms of HACE. |
| format | Article |
| id | doaj-art-bf668b13a55b4961ae8ebba84f770c1f |
| institution | Kabale University |
| issn | 2158-3188 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj-art-bf668b13a55b4961ae8ebba84f770c1f2025-08-20T03:46:21ZengNature Publishing GroupTranslational Psychiatry2158-31882025-07-0115111210.1038/s41398-025-03469-2Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in miceQiang Fu0Rui Qiu1Quan Tang2Xiaodong Li3Yaobo Li4Yuxiang Qin5Qiaosheng Li6Jia Yao7Zhongyong Jiang8Huan Xu9Yong Cheng10Institute of National Security, Center on Translational Neuroscience, Minzu University of ChinaInstitute of National Security, Center on Translational Neuroscience, Minzu University of ChinaCollege of Life and Environmental Sciences, Minzu University of ChinaCollege of Life and Environmental Sciences, Minzu University of ChinaCollege of Life and Environmental Sciences, Minzu University of ChinaCollege of Life and Environmental Sciences, Minzu University of ChinaCollege of Life and Environmental Sciences, Minzu University of ChinaCollege of Life and Environmental Sciences, Minzu University of ChinaDepartment of Medical Laboratory, Affiliated Cancer Hospital of Chengdu Medical College, Chengdu Seventh People’s HospitalDepartment of Clinical Laboratory, General Hospital of Xizang Military CommandInstitute of National Security, Center on Translational Neuroscience, Minzu University of ChinaAbstract The impact of exosomes derived from patients with High Altitude Cerebral Edema (HACE) on cognitive function in mice was investigated, along with the underlying mechanisms. Exosomes were extracted from HACE patients and injected into the dentate gyrus (DG) of mice. A series of behavioral tests assessed cognitive abilities. Results indicated that mice injected with HACE patient exosomes exhibited significant declines in exploratory behavior and object recognition, suggesting notable cognitive impairments. Additionally, these exosomes induced oxidative stress responses and abnormal activation of microglia, closely associated with neuronal death. Proteomic analysis revealed that the differentially expressed protein STAMBP, which is closely linked to neurodevelopment, may play a key role. In conclusion, our findings highlight the potential impact of exosomes from HACE patients on cognitive dysfunction in mice, providing new insights into the pathophysiological mechanisms of HACE.https://doi.org/10.1038/s41398-025-03469-2 |
| spellingShingle | Qiang Fu Rui Qiu Quan Tang Xiaodong Li Yaobo Li Yuxiang Qin Qiaosheng Li Jia Yao Zhongyong Jiang Huan Xu Yong Cheng Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice Translational Psychiatry |
| title | Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice |
| title_full | Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice |
| title_fullStr | Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice |
| title_full_unstemmed | Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice |
| title_short | Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice |
| title_sort | exosomes from high altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice |
| url | https://doi.org/10.1038/s41398-025-03469-2 |
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