Nigral volume loss in prodromal, early, and moderate Parkinson’s disease
Abstract The loss of melanized neurons in the substantia nigra pars compacta (SNc) is a hallmark pathology in Parkinson’s disease (PD). Melanized neurons in SNc can be visualized in vivo using magnetization transfer (MT) effects. Nigral volume was extracted in data acquired with a MT-prepared gradie...
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| Main Authors: | Jason Langley, Kristy S. Hwang, Daniel E. Huddleston, Xiaoping P. Hu, On behalf of the Parkinson’s Progression Marker Initiative |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-06-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00976-3 |
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