Nigral volume loss in prodromal, early, and moderate Parkinson’s disease

Abstract The loss of melanized neurons in the substantia nigra pars compacta (SNc) is a hallmark pathology in Parkinson’s disease (PD). Melanized neurons in SNc can be visualized in vivo using magnetization transfer (MT) effects. Nigral volume was extracted in data acquired with a MT-prepared gradie...

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Bibliographic Details
Main Authors: Jason Langley, Kristy S. Hwang, Daniel E. Huddleston, Xiaoping P. Hu, On behalf of the Parkinson’s Progression Marker Initiative
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00976-3
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