Radiotherapy-induced Hypothalamic-Pituitary axis dysfunction in adult Brain, head and neck and skull base tumor patients – A systematic review and Meta-Analysis

Radiotherapy-induced Hypothalamic-Pituitary axis dysfunction in adult Brain, head and neck and skull base tumor patients – A systematic review and Meta-Analysis

Background and purpose: Radiotherapy for brain, head & neck (HN), and skull base (SB) tumors may deliver significant radiation dose to the hypothalamic-pituitary axis (HPA), leading to impaired functioning of this region and hence, to endocrine disorders. The purpose of this systematic revie...

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Main Authors: J.M.J. Paulissen, C.M.L. Zegers, R.M. Houben, D. Hofstede, M. Kars, H.M. van Santen, F.J.P. Hoebers, D.K.M. De Ruysscher, D.B.P. Eekers
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Hypothalamic-pituitary dysfunction
Insufficiency
Endocrine
Brain
Head and neck
Skull base
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630824001770
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