Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis

Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis

Abstract Glioblastoma multiforme (GBM) is characterized by pronounced immune escape and resistance to chemotherapy-induced apoptosis. Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM. Notably, cisplatin (CDDP) demonstrated a capacity of inducing pyroptosis by...

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Main Authors: Xinyan Hao, Yucheng Tang, Wenjie Xu, Ming Wang, Jiayi Liu, Yongjiang Li, Jun He, Yanjin Peng, Pengcheng Sun, Dehua Liao, Xiongbin Hu, Tiantian Tang, Min Zhou, Ruyue Han, Jiemin Wang, João Conde, Daxiong Xiang, Junyong Wu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Nanobiotechnology
Subjects:
Glioblastoma
Pyroptosis
Cisplatin
Programmed death-1
Chemo-immunotherapy
Online Access:https://doi.org/10.1186/s12951-025-03091-w
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https://doi.org/10.1186/s12951-025-03091-w

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