Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma

Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma

Increasing evidence demonstrates the immunosuppressive kynurenine pathway’s (KP) role in the pathophysiology of human gliomas. To study the KP in vivo, we used the noninvasive molecular imaging tracer α-[ 11 C]-methyl- l -tryptophan (AMT). The AMT-positron emission tomography (PET) has shown high up...

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Main Authors: Anthony R. Guastella BS, Sharon K. Michelhaugh PhD, Neil V. Klinger MS, William J. Kupsky MD, Lisa A. Polin PhD, Otto Muzik PhD, Csaba Juhász MD, PhD, Sandeep Mittal MD, FRCSC, FACS
Format: Article
Language:English
Published: SAGE Publishing 2016-04-01
Series:Molecular Imaging
Online Access:https://doi.org/10.1177/1536012116644881
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https://doi.org/10.1177/1536012116644881

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