β-catenin safeguards cell survival via a transcription-independent mechanism during the induction of primitive streak from hESCs

Abstract The emergence of the primitive streak, representing an organizing center for gastrulation, marks the mesendodermal lineage specification from epiblast, in which the epiblast cells undergo highly organized collective behaviors to form mesendodermal cells properly. Cell death is observed at t...

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Bibliographic Details
Main Authors: Peng Zhang, Xu-Xia Li, Hua-Jun Bai, Yongxu Zhao, Senle Rao, He Liang, Xiao-Ling Luo, Huang-Tian Yang
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02559-w
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