Efficient strategy for alleviating neuronal apoptosis and oxidative stress damage of Alzheimer's disease through dual targeting BCL-2 gene promoter i-motif and β-amyloid

Efficient strategy for alleviating neuronal apoptosis and oxidative stress damage of Alzheimer's disease through dual targeting BCL-2 gene promoter i-motif and β-amyloid

Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized by abnormal metabolism of β-amyloid (Aβ) precursor proteins and neuronal apoptosis, ultimately leading to cognitive dysfunction. The pathogenesis of AD is complex, and current single-target therapies are not effective...

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Bibliographic Details
Main Authors: Dongsheng Ji, Jiahui Zhang, Jihai Liang, Zhi-Shu Huang, Bing Shu, Ding Li
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Redox Biology
Subjects:
Alzheimer's disease
BCL-2
I-motif
β-amyloid (Aβ)
Oxidative stress
anti-Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001132
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