Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation

Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation

Objectives: There is renewed interest in targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) for treatment of obesity and type 2 diabetes. G-protein coupled receptor desensitisation is suggested to reduce the long-term efficacy of glucagon-like-peptide 1 receptor (GLP-1R) agon...

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Main Authors: Iona Davies, Alice E. Adriaenssens, William R. Scott, David Carling, Kevin G. Murphy, James S. Minnion, Stephen R. Bloom, Ben Jones, Tricia M-M. Tan
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Molecular Metabolism
Subjects:
Glucose-dependent insulinotropic polypeptide receptor (GIPR)
Receptor desensitisation
β-arrestin
Receptor internalisation
Obesity
Type 2 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000018
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