Bacteria-induced uroplakin signaling mediates bladder response to infection.

Urinary tract infections are the second most common infectious disease in humans and are predominantly caused by uropathogenic E. coli (UPEC). A majority of UPEC isolates express the type 1 pilus adhesin, FimH, and cell culture and murine studies demonstrate that FimH is involved in invasion and apo...

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Bibliographic Details
Main Authors: Praveen Thumbikat, Ruth E Berry, Ge Zhou, Benjamin K Billips, Ryan E Yaggie, Tetiana Zaichuk, Tung-Tien Sun, Anthony J Schaeffer, David J Klumpp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000415&type=printable
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