EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals

Abstract The known universe of uncharacterized proteins is expanding far faster than our ability to annotate their functions through laboratory study. Computational annotation approaches rely on similarity to previously studied proteins, thereby ignoring unstudied proteins. Coevolutionary approaches...

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Bibliographic Details
Main Authors: Aidan H. Lakshman, Erik S. Wright
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59175-6
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