Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer

Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer

Abnormal amino acid metabolism promotes tumor progression by inducing malignant behaviors in tumor cells and altering the immune landscape within the tumor microenvironment. However, the underlying mechanisms remain unclear. In this study, we constructed colorectal cancer (CRC) organoids and patient...

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Main Authors: Yujie Zhang, Weiyi Zhao, Ling Wu, Tianjing Ai, Jie He, Zetao Chen, Chuangyuan Wang, Hui Wang, Rui Zhou, Chaoqun Liu, Liang Zhao
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Colorectal cancer
CCT5
Asparagine metabolism
ASNase
Anti-PD-L1 immunotherapy
Combination therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525001637
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