Phα1β interaction with the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG channel

Phα1β interaction with the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG channel

Abstract Background: This study examines the impact of Phα1β, a spider peptide derived from the venom of Phoneutria nigriventer, on the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG potassium channel. Phα1β inhibits high-voltage calcium channels and acts as an antagonist o...

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Bibliographic Details
Main Authors: João B. Calixto, Adara Aurea dos Santos, Juliano Ferreira, Alessandra Hubner Souza, Célio José de Castro Junior, Marcus Vinicius Gomez
Format: Article
Language:English
Published: SciELO 2025-01-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Phα1β
analgesic
Dofetilide
Kv11.1 potassium channel
hERG channel interaction
HEK293-hERG
cell viability
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992025000100501&lng=en&tlng=en
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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992025000100501&lng=en&tlng=en

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