Anticancer Quinolinol Small Molecules Target Multiple Pathways to Promote Cell Death and Eliminate Melanoma Cells Resistant to BRAF Inhibitors

Anticancer Quinolinol Small Molecules Target Multiple Pathways to Promote Cell Death and Eliminate Melanoma Cells Resistant to BRAF Inhibitors

Small molecule inhibitors that target the E3 ligase activity of MDM2-MDM4 have been explored to inhibit the oncogenic activity of MDM2-MDM4 complex. MMRi62 is a small molecule that was identified using an MDM2-MDM4 E3 ligase-based high throughput screen and a cell-death-based secondary screen. Our p...

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Bibliographic Details
Main Authors: Xinjiang Wang, Rati Lama, Alexis D. Kelleher, Erika C. Rizzo, Samuel L. Galster, Chao Xue, Yali Zhang, Jianmin Wang, Jun Qu, Sherry R. Chemler
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
MMRi62
quinolinol
MDM2-MDM4
E3 ligase
cell death
targets
Online Access:https://www.mdpi.com/1420-3049/30/13/2696
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