Cancer-associated fibroblast driven paracrine IL-6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma

Cancer-associated fibroblast driven paracrine IL-6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma

Abstract Background Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer after invasive ductal carcinoma of no special type (NST), accounting for 10–15% of diagnoses. Despite the myriad molecular, histological and clinical differences between ILC and NST t...

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Main Authors: Esme Bullock, Aleksandra Rozyczko, Sana Shabbir, Ifigenia Tsoupi, Adelaide I.J. Young, Jana Travnickova, Laura Gómez-Cuadrado, Zeanap Mabruk, Giovana Carrasco, Elizabeth Morrow, Kathryn Pennel, Pim Kloosterman, Julia M Houthuijzen, Jos Jonkers, Lidia Avalle, Valeria Poli, Richard Iggo, Xue Xiao, Jingjing Guo, Xuan Zhu, Elizabeth Mallon, Joanne Edwards, E. Elizabeth Patton, Valerie G. Brunton
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Breast Cancer Research
Online Access:https://doi.org/10.1186/s13058-025-02074-x
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https://doi.org/10.1186/s13058-025-02074-x

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