Chemical Constituents from the Fruit of <i>Melia azedarach</i> and Their Anti-Inflammatory Activity
Phytochemical investigations of <i>Melia azedarach</i> fruits have led to the isolation of a novel tirucallane triterpenoid (<b>1</b>), four new limonoids (<b>2</b>–<b>5</b>), and four known limonoids (<b>6</b>–<b>9</b>). Their...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/13/11/1338 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Phytochemical investigations of <i>Melia azedarach</i> fruits have led to the isolation of a novel tirucallane triterpenoid (<b>1</b>), four new limonoids (<b>2</b>–<b>5</b>), and four known limonoids (<b>6</b>–<b>9</b>). Their structures were clarified by comprehensive spectroscopic and spectrometric analyses. The anti-inflammatory activities of isolated compounds were assessed in vitro. Compound <b>2</b> exhibited the most potent anti-inflammatory effect, with an IC<sub>50</sub> value of 22.04 μM. Additionally, compound <b>2</b> attenuated LPS-induced reactive oxygen species (ROS) production and reduced the levels of inflammatory mediators IL-6 and TNF-<i>α</i>. A mechanistic study revealed that limonoid <b>2</b> suppresses the expression of iNOS and JAK2 and is implicated in the modulation of the NF-κB signaling cascade, which reveals its anti-inflammatory actions. |
|---|---|
| ISSN: | 2076-3921 |