Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson’s disease mice

Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson’s disease mice

Abstract Background Parkinson’s disease (PD) is a neurodegenerative disease whose cause and molecular mechanism remain unclear. Dingzhen pill (DZP), a water extract from crude herbs, is thought to possibly play a neuroprotective role in PD. However, the underlying pharmacological mechanisms of the D...

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Bibliographic Details
Main Authors: Gaoshuang Fu, Ting Li, Yukun Zhao, Shuai Zhang, Xin Xue, Yuqin Yang, Tingyu Li, Shaohan Luo, Guangxin Yue, Tong Lei
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Chinese Medicine
Subjects:
Parkinson’s disease
Proteomics
Traditional Chinese Medicine
Neuroinflammation
Ferroptosis
Network pharmacology
Online Access:https://doi.org/10.1186/s13020-025-01135-9
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https://doi.org/10.1186/s13020-025-01135-9

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