Arecoline alleviates autism spectrum disorder-like behaviors and cognition disorders in a valproic acid mouse model by activating the AMPK/CREB/BDNF signaling pathway

Arecoline alleviates autism spectrum disorder-like behaviors and cognition disorders in a valproic acid mouse model by activating the AMPK/CREB/BDNF signaling pathway

Studies in humans have revealed that the pathogenesis of autism spectrum disorder (ASD) is linked to white matter abnormalities involving hypomyelination and oligodendroglia dysfunction; however, effective treatments remain limited. Similarly, the valproic acid (VPA) model mice, which are widely use...

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Bibliographic Details
Main Authors: Chunyan Wen, Zhizhong Xu, Fengling Cao, Qianfa Yuan, Weichao Su, Zhiyuan Huang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Brain Research Bulletin
Subjects:
Autism spectrum disorder
Cognition
Myelination
Arecoline
AMPK signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025002436
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