A novel CD44-targeting aptamer recognizes chemoresistant mesenchymal stem-like TNBC cells and inhibits tumor growth

A novel CD44-targeting aptamer recognizes chemoresistant mesenchymal stem-like TNBC cells and inhibits tumor growth

Triple-negative breast cancer (TNBC) represents a significant therapeutic challenge owing to the scarcity of targeted medicines and elevated recurrence rates. We previously reported the development of the nuclease-resistant RNA sTN58 aptamer, which selectively targets TNBC cells. Here, sTN58 aptamer...

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Bibliographic Details
Main Authors: Alessandra Caliendo, Simona Camorani, Luis Exequiel Ibarra, Gabriella Pinto, Lisa Agnello, Sandra Albanese, Antonietta Caianiello, Anna Illiano, Rosaria Festa, Vincenzo Ambrosio, Giosuè Scognamiglio, Monica Cantile, Angela Amoresano, Monica Fedele, Antonella Zannetti, Laura Cerchia
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-08-01
Series:Bioactive Materials
Subjects:
Aptamer
CD44
Chemoresistant triple-negative breast cancer
Biomarker identification
Targeted cancer therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25001756
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http://www.sciencedirect.com/science/article/pii/S2452199X25001756

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