The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis
The studies outlined in this review highlight the relationship between inflammatory signaling molecules and connexin-43 (Cx43). Gap junction (GJ) channels and hemichannels (HCs) participate in the metabolic activity between intra- and extracellular space. Some ions and small molecules are exchanged...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/9312827 |
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| author | Chu-Yang Xu Wen-Song Zhang Hong Zhang Yan Cao Hong-Yan Zhou |
| author_facet | Chu-Yang Xu Wen-Song Zhang Hong Zhang Yan Cao Hong-Yan Zhou |
| author_sort | Chu-Yang Xu |
| collection | DOAJ |
| description | The studies outlined in this review highlight the relationship between inflammatory signaling molecules and connexin-43 (Cx43). Gap junction (GJ) channels and hemichannels (HCs) participate in the metabolic activity between intra- and extracellular space. Some ions and small molecules are exchanged from cell to cell or cell to extracellular space to affect the process of inflammation via GJ. We analyzed the effects of signaling molecules, such as innate immunity messengers, transcription factors, LPS, cytokine, inflammatory chemokines, and MMPs, on Cx43 expression during the inflammatory process. At the same time, we found that these signaling molecules play a critical role in the pathogenesis of keratitis. Thus, we assessed the function of Cx43 during inflammatory corneal disease. Corneal healing plays an essential role in the late stage of keratitis. We found that Cx43 is involved in wound healing. Studies have shown that the decrease of Cx43 can decrease the time of healing. We also report several Cx43 mimic peptides which can inhibit the activity of Cx43 Hc to mediate the releasing of adenosine triphosphate (ATP), which may in turn influence the inflammatory process. |
| format | Article |
| id | doaj-art-bdf01dd68fbe4e1ab6d28c35e48d45cc |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-bdf01dd68fbe4e1ab6d28c35e48d45cc2025-02-03T01:03:12ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/93128279312827The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence KeratitisChu-Yang Xu0Wen-Song Zhang1Hong Zhang2Yan Cao3Hong-Yan Zhou4Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, Jilin Province, ChinaDepartment of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, ChinaDepartment of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, ChinaDepartment of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, ChinaThe studies outlined in this review highlight the relationship between inflammatory signaling molecules and connexin-43 (Cx43). Gap junction (GJ) channels and hemichannels (HCs) participate in the metabolic activity between intra- and extracellular space. Some ions and small molecules are exchanged from cell to cell or cell to extracellular space to affect the process of inflammation via GJ. We analyzed the effects of signaling molecules, such as innate immunity messengers, transcription factors, LPS, cytokine, inflammatory chemokines, and MMPs, on Cx43 expression during the inflammatory process. At the same time, we found that these signaling molecules play a critical role in the pathogenesis of keratitis. Thus, we assessed the function of Cx43 during inflammatory corneal disease. Corneal healing plays an essential role in the late stage of keratitis. We found that Cx43 is involved in wound healing. Studies have shown that the decrease of Cx43 can decrease the time of healing. We also report several Cx43 mimic peptides which can inhibit the activity of Cx43 Hc to mediate the releasing of adenosine triphosphate (ATP), which may in turn influence the inflammatory process.http://dx.doi.org/10.1155/2019/9312827 |
| spellingShingle | Chu-Yang Xu Wen-Song Zhang Hong Zhang Yan Cao Hong-Yan Zhou The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis Journal of Ophthalmology |
| title | The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis |
| title_full | The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis |
| title_fullStr | The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis |
| title_full_unstemmed | The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis |
| title_short | The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis |
| title_sort | role of connexin 43 in the inflammatory process a new potential therapy to influence keratitis |
| url | http://dx.doi.org/10.1155/2019/9312827 |
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