Inflammatory cytokine-primed MSC-derived extracellular vesicles ameliorate acute lung injury via enhanced immunomodulation and alveolar repair

Inflammatory cytokine-primed MSC-derived extracellular vesicles ameliorate acute lung injury via enhanced immunomodulation and alveolar repair

Abstract Background Acute lung injury (ALI) is characterized by excessive inflammation and alveolar damage, arising from pathogens or systemic insults such as sepsis, and can progress to severe acute respiratory distress syndrome (ARDS). Despite its severity, effective pharmacological treatments rem...

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Main Authors: Jongwon Jeong, Jun-Kook Park, Jiwon Shin, Inseong Jung, Hyun-Woo Kim, Anyeseu Park, Hanchae Cho, Sung-Min Kang, Sanghee Shin, Eunju Park, Jisuk Kim, Soojeong Noh, Yongdeok Ahn, Do-Kyun Kim, Jeong Yoon Lee, Daeha Seo, Moon-Chang Baek, Kyungmoo Yea
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Stem Cell Research & Therapy
Subjects:
Acute lung injury (ALI)
Mesenchymal stem cells (MSCs)
Extracellular vesicles (EVs)
Priming
Online Access:https://doi.org/10.1186/s13287-025-04576-z
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https://doi.org/10.1186/s13287-025-04576-z

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